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KMID : 1149220060140010105
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Korean Journal of Oriental Medical Prescription
2006 Volume.14 No. 1 p.105 ~ p.119
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Effects of Hwadamtongrak-Tang on the changes of Cerebral Flow in the rats
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Park Hyung-Bae
Yang Seung-Jung
Wei Tung-Sheun
Park Hye-Sun
Jeon Sang-Yun
Hong Seok
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Abstract
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Objectives & Methods : This present study was performed to investigate the effect of Hwadamtongrak-Tang extract (HTT) on the regulation of cerebral hemodynamics in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP)] in normal and cerebral ischemic rats. Also the effects of HTT on changes in local blood flow, inhibition of LD H activity in neuronal cells, and levels of cytokine production in the serum were determined in the ischemic rat model. The major findings are summarized below.
Results : 1. HTT significantly increased rCBF in a dose-dependent manner, but MABP was not changed by HTT treatment. These results suggest that HTT may increase rCBF by dilating cerebral arterial diameter. 2. HTT-induced increase in rCBF was blocked by pretreatment with cyclooxygenase inhibitor indomethacin (IDN, 1 mg/kg, i.p.) and MABP was significantly increased by ID N. 3. Pretreatment of methylene blue (MTB, 10 ㎍/kg, i.p.), an inhibitor of guanylate cyclase, significantly decreased both rCBP and MABP in HTT-treated rats. 4. HTT treatment significantly increased rCBP to a stable level during the period of cerebral reperfusion. 5. HTT significantly inhibited LD H activity in neuronal cells, suggesting a neuroprotection by HTT. 6. Serum interleukin (1L)-1β and tumor necrosis factor TNF-α levels were significantly decreased in the femoral artery 1 hr after middle cerebral arterial occlusion in HTT-treated rats. IL-10 levels in the serum were significantly increased by HTT treatment whereas transforming growth factor TNF-β levels were similar between HTT-treated and control groups. 7. Serum interleukin (1L)-1β and tumor necrosis factor TNF-α levels were significantly decreased in the femoral artery 1 hr after reperfusion in HTT-treated rats. Serum IL-10 levels were significantly decreased in HTT-treated rats compared with the control group, and no significant changes in TNF-β in the serum were observed by HTT treatment.
Conclusions: The present data suggest that HTT may have an anti-ischemic effect via the improvement of cerebral hemodynamics and thus protect the brain from ischemic damage.
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KEYWORD
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Hwadamtongrak-Tang, regional cerebral blood flow(rCBF), mean arterial blood pressure(MABP), LDH, cytokine
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